Biomarkers in Atopic Dermatitis and Psoriasis

akronüüm: BIOMAP
algus: 2019-04-01
lõpp: 2024-03-31
 
programm: H2020 - Horisont 2020
alaprogramm: HEALTH - Tervishoid, demograafilised muutused ja heaolu
instrument: JTI-IMI2-RIA
projektikonkurss: H2020-JTI-IMI2-2017-13-two-stage
projekti number: 821511
kestus kuudes: 60
partnerite arv: 32
 
lühikokkuvõte: Our objective is to provide a taxonomic and predictive systems medicine model of Atopic Dermatitis and Psoriasis based on clinical and molecular profiling to (i) identify determinants of clinically relevant outcomes (disease manifestation, progression, comorbidity development and treatment response) (ii) improve understanding on shared and distinct disease mechanism(s) and associated signatures, and their relative importance in patient subpopulations and (iii) deliver biomarkers that identify disease trajectories and treatment response for use in drug development and clinical practice. BIOMAP will create a biospecimen and data resource of unprecedented scale and depth, accessible via a central data and analysis portal, harmonizing diverse, high quality, multi-dimensional datasets on skin and blood (whole and single cell), large scale population-based and trial data; parallel clinical research infrastructure will deliver supplementary material flexible to the needs of the consortium. This resource will be systematically analyzed using state-of-the-art methodologies in epidemiology, molecular profiling, skin biology and mathematical modelling to define disease and drug endotypes and how these interact with lifestyle and environmental factors. Selected, highly discriminatory, associated biomarkers will pass through a diagnostics pipeline (novel in-silico trial methods and assay development), ready for immediate translation. BIOMAP is expected to drive drug discovery to target causal mechanisms, shorten drug development pathways, and fundamentally change the diagnosis and management paradigm, from re-active to pro-active strategies that encompass disease biology and life-time trajectory, matching the intervention (prevention, modification of risk factors, therapeutics) with endotypes. Clinically annotated endotypes and associated biomarkers will identify when, in whom and how to intervene to minimize disease impact and improve outcomes.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL DE Stephan WEIDINGER http://www.uni-kiel.de
2 partner KING'S COLLEGE LONDON UK www.kcl.ac.uk
3 partner KAROLINSKA INSTITUTET SE www.ki.se
4 partner ACADEMISCH ZIEKENHUIS LEIDEN NL www.lumc.nl
5 partner UNIVERSITE DU LUXEMBOURG LU www.uni.lu
6 partner TAMPEREEN KORKEAKOULUSAATIO SR FI https://www.tuni.fi/en
7 partner KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN DE http://www.med.tu.muenchen.de
8 partner AIT AUSTRIAN INSTITUTE OF TECHNOLOGY GMBH AT http://www.ait.ac.at/
9 partner UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE www.uke.uni-hamburg.de
10 partner UNIVERSITY OF BRISTOL UK www.bristol.ac.uk
11 partner UNIVERSITY OF DUNDEE UK www.dundee.ac.uk
12 partner KOBENHAVNS UNIVERSITET DK www.ku.dk
13 partner DEN SELVEJENDE INSTITUTION DANSK BORNEASTMA CENTER DK www.copsac.com
14 partner STICHTING KATHOLIEKE UNIVERSITEIT NL www.ru.nl
15 partner Tartu Ülikool EE http://www.ut.ee
16 partner CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS CH www.chuv.ch
17 partner ITA-SUOMEN YLIOPISTO FI www.uef.fi
18 partner HEINRICH-HEINE-UNIVERSITAET DUESSELDORF DE www.uni-duesseldorf.de
19 partner THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN E IE www.tcd.ie
20 partner ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM NL www.amc.nl
21 partner INFORMATION TECHNOLOGY FOR TRANSLATIONAL MEDICINE (ITTM) SA LU www.ittm-solutions.com
22 partner HAHN-SCHICKARD-GESELLSCHAFT FUER ANGEWANDTE FORSCHUNG E.v. DE www.hahn-schickard.de
23 partner LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE ROYAL CHARTER UK
24 partner EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH DE www.eurice.eu
25 partner UNIVERSITAT WIEN AT www.univie.ac.at
26 partner SANOFI-AVENTIS DEUTSCHLAND GMBH DE www.sanofi-aventis.de
27 partner LEO PHARMA AS DK www.leo-pharma.com
28 partner BOEHRINGER INGELHEIM INTERNATIONALGMBH DE www.boehringer-ingelheim.com
29 partner PFIZER LIMITED UK www.pfizer.com
30 partner UCB BIOPHARMA SPRL BE www.ucb.com
31 partner TECHNISCHE UNIVERSITAET MUENCHEN DE www.tum.de