Development and Implementation of a Sustainable Modelling Platform for NanoInformatics.

akronüüm: NanoInformaTIX
algus: 2019-01-01
lõpp: 2023-02-28
 
programm: H2020 - Horisont 2020
alaprogramm: LEIT - Juhtkoht tööstustehnoloogias
instrument: RIA
projektikonkurss: H2020-NMBP-TO-IND-2018
projekti number: 814426
kestus kuudes: 50
partnerite arv: 36
 
lühikokkuvõte: NanoInformaTIX aims to create a comprehensive, sustainable, multi-scale modelling framework for exposure and (eco)-toxicity of Engineered Nanomaterials (ENM) to facilitate cost-effective risk assessment, less reliant on animal testing, and to support the design of safer materials and products. Our approach integrates several relevant EU/US databases with validated nanoinformatics models covering: Materials, Exposure, Physiologically-Based Pharmacokinetics (PBPK), Quantitative-Structure-Activity Relations (QSAR) and Systems Biology modelling and in vitro/in vivo extrapolation to support the prediction of biological effects and exposure of ENM at various stages of their life cycle and product development. NanoInformaTIX will address grouping and read-across for risk assessment and safer product design. NanoInformaTIX will use existing curated data from several completed EU/US projects and from peer-reviewed literature to develop, extend the models and will also consider emerging data from ongoing projects for model validation following the OECD validation principles. This will take the NanoInformaTIX models from TLR4 to TLR6. The NanoInformaTIX modelling framework will be a web-based platform with a user-friendly interface tailored to the needs of different stakeholders (industry, regulators, academia and the civil society). To obtain optimal confidence in the use of the NanoInformaTIX modelling and database framework, all models will be described clearly using agreed standards terminology and implemented on harmonized standard operating protocols based on Good Modelling/Software Design practices. Their applicability domain will be clearly documented and referenced for full transparency and detailed user guidance for each will be provided. NanoInformaTIX will achieve considerable impact by providing the much -needed validated accessible data management modelling framework to predict human and environmental risks, to support the design of sustainable ENM and products.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES Miguel BANARES http://www.csic.es
2 partner INSTITUTE OF OCCUPATIONAL MEDICINE UK www.iom-world.org
3 partner EUROPEAN RESEARCH SERVICES GMBH DE www.european-research-services.eu
4 partner AARHUS UNIVERSITET DK www.au.dk
5 partner BUNDESINSTITUT FUER RISIKOBEWERTUNG DE www.bfr.bund.de
6 partner GREENDECISION SRL IT
7 partner THOMAS MORE KEMPEN VZW BE www.thomasmore.be
8 partner TEL AVIV UNIVERSITY IL http://www.tau.ac.il/
9 partner UNIWERSYTET GDANSKI PL www.ug.edu.pl
10 partner UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN IE www.ucd.ie
11 partner UNIVERSITAT ROVIRA I VIRGILI ES http://www.urv.cat
12 partner IDEACONSULT LIMITED LIABILITY COMPANY BG http://www.ideaconsult.net/
13 partner HELSINGIN YLIOPISTO FI www.helsinki.fi
14 partner UNIVERSITEIT LEIDEN NL http://www.leidenuniv.nl
15 partner SINTEF OCEAN AS NO http://www.sintef.no/ocean
16 partner UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA IT www.web.uniroma2.it
17 partner NATIONAL TECHNICAL UNIVERSITY OF ATHENS - NTUA EL www.ntua.gr
18 partner UNIVERSIDADE DE AVEIRO PT www.ua.pt
19 partner EIDGENOSSISCHE MATERIALPRUFUNGS- UND FORSCHUNGSANSTALT CH www.empa.ch
20 partner UPPINTECH OU EE http://uppin.vunts.com
21 partner NATIONAL CENTER FOR SCIENTIFIC RESEARCH "DEMOKRITOS" EL www.demokritos.gr
22 partner POLITECNICO DI TORINO IT www.polito.it
23 partner WARRANT HUB SPA IT www.warrantgroup.eu
24 partner TEMAS AG TECHNOLOGY AND MANAGEMENT SERVICES CH www.temas.ch
25 partner CONSIGLIO NAZIONALE DELLE RICERCHE IT www.cnr.it
26 partner DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK www.nrcwe.dk
27 partner TYOTERVEYSLAITOS FI www.ttl.fi
28 partner SWANSEA UNIVERSITY UK www.swan.ac.uk
29 partner UNIVERSITE D'AIX MARSEILLE FR
30 partner MINTEK ZA www.mintek.co.za
31 partner HELMHOLTZ-ZENTRUM FUR UMWELTFORSCHUNG GMBH - UFZ DE www.ufz.de
32 partner EAST EUROPEAN RESEARCH AND INNOVATION ENTERPRISE LTD BG www.emerge.bg
33 partner NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY, CHINA CN www.nanoctr.cn
34 partner NATIONAL CHENG KUNG UNIVERSITY TW
35 partner SORBONNE UNIVERSITE FR
36 partner UNIVERSITE CATHOLIQUE DE L'OUEST ASSOCIATION SAINT YVES FR www.uco.fr