Effects of Nutrition and Lifestyle on Impulsive, Compulsive, and Externalizing behaviours

akronüüm: Eat2beNICE
algus: 2017-09-01
lõpp: 2022-08-31
 
programm: H2020 - Horisont 2020
alaprogramm: FOOD - Toiduga kindlustatus, säästev põllumajandus, mere- ja merendusuuringud ning biomajandus
instrument: RIA
projektikonkurss: H2020-SFS-2016-2
projekti number: 728018
kestus kuudes: 60
partnerite arv: 20
 
lühikokkuvõte: Maladaptive impulsivity and compulsivity predispose to antisocial and addictive behaviours. Factors influencing those traits are not well understood, but diet, lifestyle, socio-economic status (SES), sex, and heritability play pivotal roles. Here, we aim (1) to identify nutrition and lifestyle drivers that can be employed to prevent detrimental impulsivity/compulsivity in males and females across the lifespan, (2) to characterize the etiologic paths leading to extreme behaviour, and (3) to promote policy changes to counteract maladaptive impulsivity/compulsivity by disseminating evidence-based information about health-related behaviours to families, clinicians, policy makers, and general public. We use epidemiologic approaches in the world-wide largest existing samples to investigate association of nutrition components & lifestyle with impulsivity/ compulsivity, and how such associations are moderated by age, culture, sex, SES, and genetics. We assess beneficial effects of key nutritional interventions through RCTs in highly impulsive males/females, going beyond state-of-the-art by directly comparing personalized, high-intensity approaches with one-size-fits-all and microbiome-dependent supplementations. We study the protective potential of acute exercise and habitual physical activity. We monitor intervention-induced changes in real time through objective mHealth-based experience sampling. Uniquely, we study effects of the gut-microbiome and its metabolites, as well as brain connectivity and epigenetic patterns as mediators and predictors of behavioural change. We initiate and support societal change by media-based information and education. We innovate the field by measuring behavioural change using social media downstream of educational campaigns and by translation of our findings into tangible healthy food solutions with a celebrity chef. Our group, in which experts from multiple disciplines join forces, is in a unique position to carry out the proposed project.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator STICHTING KATHOLIEKE UNIVERSITEIT NL Alejandro ARIASVASQUEZ www.ru.nl
2 partner STICHTING KARAKTER NL www.karakter.com
3 partner JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE www.uni-frankfurt.de
4 partner UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT DE www.uk-wuerzburg.de
5 partner UNIVERSITAT DE BARCELONA ES http://www.ub.edu
6 partner FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES http://www.vhir.org
7 partner UNIVERSITETET I BERGEN NO www.uib.no
8 partner Tartu Ülikool EE www.ut.ee
9 partner ACADEMISCH ZIEKENHUIS GRONINGEN NL www.umcg.nl
10 partner ZENTRALINSTITUT FUER SEELISCHE GESUNDHEIT DE www.zi-mannheim.de
11 partner WAGENINGEN UNIVERSITY NL http://www.wageningenur.nl/nl.htm
12 partner Concentris Research Management GmbH DE www.concentris.de
13 partner OREBRO UNIVERSITY SE www.oru.se
14 partner SEMMELWEIS EGYETEM HU http://semmelweis.hu
15 partner CONSORCIO CENTRO DE INVESTIGACION BIOMEDICA EN RED M.P. ES www.ciberisciii.es
16 partner KARLSRUHER INSTITUT FUER TECHNOLOGIE DE www.kit.edu
17 partner STICHTING BURO ECNP NL www.ecnp.eu
18 partner ADD INFORMATION SERVICES UK www.addiss.co.uk