Validating C. elegans healthspan model for better understanding factors causing health and disease, to develop evidence based prevention, diagnostic, therapeutic and other strategies.

akronüüm: Ageing with elegans
algus: 2015-05-01
lõpp: 2020-04-30
 
programm: H2020 - Horisont 2020
alaprogramm: HEALTH - Tervishoid, demograafilised muutused ja heaolu
instrument: RIA
projektikonkurss: H2020-PHC-2014-two-stage
projekti number: 633589
kestus kuudes: 60
partnerite arv: 17
 
lühikokkuvõte: Healthspan (the life period when one is generally healthy and free from serious disease) depends on nature (genetic make-up) and nurture (environmental influences, from the earliest stages of development throughout life). Genetic studies increasingly reveal mutations and polymorphisms that may affect healthspan. Similarly, claims abound about lifestyle modifications or treatments improving healthspan. In both cases, rigorous testing is hampered by the long lifespan of model organisms like mice (let alone humans) and the difficulty of introducing genetic changes to examine the phenotype of the altered genome. We will develop C. elegans as a healthspan model. Already validated extensively as an ageing model, this organism can be readily modified genetically, and effects of environmental manipulations on healthspan can be measured in days or weeks. Once validated as a healthspan model, it can be used for an initial assessment of preventive and therapeutic measures for humans, as well as for risk identification and the initial evaluation of potential biomarkers. It will also prove useful to study interactions between genetic and various environmental factors.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator KATHOLIEKE UNIVERSITEIT LEUVEN BE Walter LUYTEN http://www.kuleuven.be
2 partner UNIVERSITEIT GENT BE http://www.ugent.be
3 partner UNIVERSITATSMEDIZIN ROSTOCK DE http://www.med.uni-rostock.de
4 partner IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK http://www.imperial.ac.uk
5 partner HUMBOLDT-UNIVERSITAET ZU BERLIN DE http://www.hu-berlin.de
6 partner TERVEYDEN JA HYVINVOINNIN LAITOS FI http://www.thl.fi
7 partner AARHUS UNIVERSITET DK http://www.au.dk
8 partner BIOPOLIS SL ES http://www.biopolis.es
9 partner EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH http://www.ethz.ch
10 partner THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA CORP US http://www.upenn.edu
11 partner AnalytiCon Discovery GmbH DE http://www.ac-discovery.com
12 partner TSINGHUA UNIVERSITY CN
13 partner CARTAGENIA NV BE http://www.cartagenia.com
14 partner ISTITUTO SUPERIORE DI SANITA IT http://www.iss.it
15 partner ABIOMICS EUROPE KFT HU http://www.abiomics.eu
16 partner Tartu Ülikool EE http://www.ut.ee
17 partner KAROLINSKA INSTITUTET SE http://www.ki.se