Biomarker for Cardiovascular Risk Assessment in Europe

akronüüm: BIOMARCARE
algus: 2011-10-01
lõpp: 2015-09-30
 
programm: FP7 - Euroopa Liidu 7. raamprogramm
alaprogramm: HEALTH - Tervis
instrument: CP-FP - Väikese- ja keskmisemahulised koostööprojektid
projektikonkurss: FP7-HEALTH-2011-two-stage
projekti number: 278913
kestus kuudes: 48
partnerite arv: 29
 
lühikokkuvõte: Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain. Based on harmonised and standardised European population cohorts we have built significant research collaboration, expertise and infrastructure in the EU. We will apply highly innovative SME-driven technologies and perform large-scale biomarker determination to assess the predictive value of existing and emerging biomarkers. Selection of emerging biomarkers will be based on integrated cutting-edge quantitative proteomic, transcriptomic, metabolomic, and miRNomic datasets established by private and public consortium members that will be disclosed to this consortium. Existing biomarkers will be selected based on non-redundancy and their association with cardiovascular risk and phenotypes. After SME-guided development of innovative assay systems biomarkers will be tested and validated in a stepwise fashion among European populations in primary and secondary prevention. In addition to their impact on risk prediction, their association with lifestyle determinants and cardiovascular phenotypes assessed by ultrasound and MRI technique will be evaluated. We will establish a BiomarCaRE panel which leads to improved disease prediction among different European populations. International collaborations with world-class clinical trial investigators will add data on the interaction of the BiomarCaRE panel with risk-lowering medication and lifestyle changes. The outcome of SME-driven technology development and clinical validation will undergo a medical technology assessment. The determination of cost-effectiveness will guide further clinical evaluation. These studies will reveal new methods of improved cardiovascular risk estimation and will open the path towards personalised medicine.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE Tanja Zeller http://www.uke.uni-hamburg.de
2 partner TERVEYDEN JA HYVINVOINNIN LAITOS FI Kari Kuulasmaa http://www.thl.fi
3 partner CAVADIS BV NL Heico Breek http://www.cavadis.com
4 partner UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL Gerard Pasterkamp http://www.umcutrecht.nl
5 partner HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE Jürgen Ertel http://www.helmholtz-muenchen.de
6 partner BIOCRATES LIFE SCIENCES AG AT Markus Speiser http://www.biocrates.com
7 partner UNIVERSITAET ZU LUEBECK DE Gabriele Schatton http://www.uni-luebeck.de
8 partner UMIT- PRIVATE UNIVERSITAT FUER GESUNDHEITSWISSENSCHAFTEN, MEDIZINISCHEINFORMATIK UND TECHNIK GMBH AT Petra Schnell-Inderst
9 partner MEDIZINISCHE HOCHSCHULE HANNOVER DE Frank Dittrich http://www.mh-hannover.de
10 partner FLEET BIOPROCESSING LIMITED UK Adrian Wilkinson http://www.fleetbioprocessing.co.uk
11 partner BIOCARTIS SA CH Patrick Van Den Bogaard http://www.biocartis.com
12 partner RESEARCH NETWORK SERVICES LIMITED UK Erik Werner http://www.rns4u.com
13 partner UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE Uta Veith http://www.um-mainz.de/
14 partner UNIVERSITETET I TROMSOE NO Anne Fismen http://uit.no/
15 partner UNIVERSITA CATTOLICA DEL SACRO CUORE IT Filippo Leone http://www.unicattolica.it
16 partner ERNST-MORITZ-ARNDT-UNIVERSITÄT GREIFSWALD DE Andrea Völker
17 partner UNIVERSITY COLLEGE LONDON UK Gerta Borg-Carbott http://www.ucl.ac.uk
18 partner QUEEN'S UNIVERSITY BELFAST UK Colleen Spence http://www.qub.ac.uk
19 partner INSTITUT PASTEUR DE LILLE FONDATION FR Fabienne Jean http://www.pasteur-lille.fr
20 partner CONSORCI INSTITUT CATALÀ DE CIÈNCIES CARDIOVASCULARS ES Joaquim Escobar http://en.iccc.cat
21 partner UMEA UNIVERSITET SE Lars Wikman http://www.umu.se
22 partner Tartu Ülikool EE Merike Leego http://www.ut.ee
23 partner REGION HOVEDSTADEN DK Gitte Fogelberg http://www.regionh.dk
24 partner UNIVERSITA DEGLI STUDI DELL'INSUBRIA IT Giovanni Barbieri http://www.uninsubria.it
25 partner UNIVERSITY OF DUNDEE UK Jim Mcgregor http://www.dundee.ac.uk
26 partner UNIVERSITAETSSPITAL BASEL CH Thomas Gruberski
27 partner UNIVERSITAET ULM DE Frank Gleixner
28 partner HAMILTON HEALTH SCIENCES CORPORATION CA Beena Cracknell
29 partner THE UNIVERSITY OF SYDNEY AU Kate Taylor http://www.usyd.edu.au/