Understanding and combating human age-related muscle weakness

akronüüm: MYOAGE
algus: 2009-01-01
lõpp: 2012-12-31
 
programm: FP7 - Euroopa Liidu 7. raamprogramm
alaprogramm: HEALTH - Tervis
instrument: CP-IP - Suuremahulised integreeritud projektid
projektikonkurss: FP7-HEALTH-2007-B
projekti number: 223576
kestus kuudes: 48
partnerite arv: 18
 
lühikokkuvõte: Ageing of skeletal muscle results in a progressive loss of mobility that decreases the quality of life and has major economic and social consequences for society at large. Increasing muscle weakness is a major component of muscle ageing. In the elderly muscles become atrophic (loss in muscle mass) and weaker (loss in muscle force), more susceptible to damage and consequently regenerate and recover more slowly than was the case in their youth. The challenge for FP7 is to identify the relative importance of sarcopaenia, thus proposing standards to define healthy ageing in order to identify age-related muscle weakness; secondly to identify molecular pathways which may be targeted to combat normal age related muscle weakness, and thirdly to identify therapeutic strategies to prevent muscle loss and weakness and enhance recovery following injury or immobilisation. The approaches which we will take to understand and combat muscle weakness in the aged population and improve healthspan can be defined in several steps: the collection and collation of data and samples, the assessment of physiological and functional parameters, the understanding of the various biological mechanisms involved, leading through integration to the development of strategies and their translation for the general European population. In order to develop and propose the general public with efficient countermeasures, the consortium will integrate data from genetics and epidemiology, molecular and cellular biology, physiology, biomechanics, as well as clinical and public health aspects, to ensure optimal scientific synergy from the leading European specialists and companies.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) FR Mihaja Auguste http://www.inserm.fr
2 partner FONDAZIONE PER LA RICERCA BIOMEDICA AVANZATA ONLUS IT Carla Tonin http://www.vimm.it
3 partner UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA IT Daniela Merelli http://www.uniroma1.it
4 partner REGION HOVEDSTADEN DK Inge Holm http://www.regionh.dk
5 partner THE MANCHESTER METROPOLITAN UNIVERSITY UK Maggy Taylor http://www.mmu.ac.uk
6 partner ALMA MATER STUDIORUM-UNIVERSITA DI BOLOGNA IT Andrea Previti http://www.unibo.it
7 partner UNIVERSITA DEGLI STUDI DI PAVIA IT Patrizia Bova http://www.unipv.it
8 partner ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM NL Tineke Sanchez http://www.lumc.nl
9 partner FACULTES UNIVERSITAIRES NOTRE-DAME DE LA PAIX DE NAMUR BE Daniel Bourgeois http://www.fundp.ac.be
10 partner UNIVERSITAT POMPEU FABRA ES Eva Martin
11 partner UNIVERSITA DEGLI STUDI DI PADOVA IT Paolo Bernardi http://www.unipd.it
12 partner UNIVERSITE PIERRE ET MARIE CURIE - PARIS 6 FR Thomas Wiest http://www.upmc.fr
13 partner KAYSER ITALIA SRL IT Valfredo Zolesi http://www.kayser.it
14 partner UNILEVER U.K. CENTRAL RESOURCES LIMITED UK Kavita Karnik http://www.unilever.com
16 partner Tartu Ülikool EE Enn Seppet http://www.ut.ee
17 partner JYVASKYLAN YLIOPISTO FI Harri Suominen http://www.jyu.fi
18 partner UPPSALA UNIVERSITET SE Inger Hedlund http://www.uu.se
19 partner INSERM - TRANSFERT SA FR Louis Jammayrac http://www.inserm-transfert.fr