Molecular Targets Open for Regulation by the gut flora – New Avenues for improved Diet to Optimize European health

akronüüm: TORNADO
algus: 2009-09-01
lõpp: 2013-08-31
 
programm: FP7 - Euroopa Liidu 7. raamprogramm
alaprogramm: KBBE - Toit, põllumajandus ja biotehnoloogia
instrument: CP-IP - Suuremahulised integreeritud projektid
projektikonkurss: FP7-KBBE-2007-2A
projekti number: 222720
kestus kuudes: 48
partnerite arv: 23
 
lühikokkuvõte: Europe is facing major diet related health problems. Attitudes to eating habits have to be changed and the benefits of alternative treatment regimes substantiated. This can only be achieved by providing guidelines regulating health claims based on scientific data. Thus, there is a unique opportunity to use gut flora in potential treatment regimes and as a preventive target for major diet related health problems. TORNADO consortium proposes a systemic and comprehensive mechanistic approach to deliver scientific data that can be compiled as guidelines for European authorities. TORNADO will determine the influence of diet on the gut flora and highlight the impact of gut flora on the immune system/other organ systems. TORNADO aims to investigate molecular targets that are subject to regulation by gut flora and diet that sustain health. This will be done by an increasing level of specificity, from (1) investigations of dietary habits and health in population cohorts, through (2) intervention studies in humans and animals and (3) analyses of the intestine and immune system, and also organs like adipocyte tissue, liver & brain, to pinpointing the impact of dietary influence on (4) cells and (5) potential functional molecular targets. TORNADO will deliver data that can be used to recommend biomarkers for evaluating effects of diet or microbes; refute, substantiate or improve health claims of existing products; generate novel functional food products. TORNADO's approach of microbe-to-mouse-to-man validation of dietary influence will enable more solid evidence for health claims and provide concrete deliverables e.g. Roadmaps to Health, Tailor-made Health-monitoring. Continuous state-of-the-art dissemination programs will increase impact. TORNADO's program will accelerate future design of personalized functional food for specific target groups. The evidence-based data delivered by TORNADO will have long lasting effects on health among European citizens well beyond 2012.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator KAROLINSKA INSTITUTET SE åsa Edström http://www.ki.se
2 partner INSTITUT PASTEUR FR Nadia Khelef http://www.pasteur.fr
3 partner QUEEN MARY AND WESTFIELD COLLEGE, UNIVERSITY OF LONDON UK Tanya Szendeffy http://www.qmul.ac.uk
4 partner VALTION TEKNILLINEN TUTKIMUSKESKUS FI Katri Kurvinen http://www.vtt.fi
5 partner HELSINGIN YLIOPISTO FI Tiina Berg http://www.helsinki.fi/university
6 partner VARSINAIS-SUOMEN SAIRAANHOITOPIIRIN KUNTAYHTYMA FI Risto Laalo
7 partner GOETEBORGS UNIVERSITET SE Margareta Ahlqwist http://www.gu.se
8 partner UNIVERSITE DE LAUSANNE CH Walter Wahli http://www.unil.ch
9 partner KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW NL Don Van Velzen http://www.knaw.nl
10 partner UMEA UNIVERSITET SE Anna Nordström http://www.umu.se
11 partner REGION HOVEDSTADEN DK Kate Livemore http://www.regionh.dk
12 partner DEBRECENI EGYETEM HU Aniko Kiss http://www.unideb.hu
13 partner DEUTSCHES INSTITUT FUER ERNAEHRUNGSFORSCHUNG POTSDAM REHBRUCKE DE Judith Schaefer http://www.dife.de
14 partner INSTITUTE OF FOOD RESEARCH UK Mary Anderson http://www.ifr.ac.uk
15 partner OY FOODFILES LTD FI Essi Sarkkinen http://www.foodfiles.com
16 partner STORKBIO EE Kristi Kurg http://www.storkbio.com
17 partner CYCLOLAB CIKLODEXTRIN KUTATO-FEJLES HU Erzsebet Szilagyi http://www.cyclolab.hu
18 partner Scandinavian Clinical Nutrition i Sverige AB SE Henrik Andersson
19 partner SOREDAB SAS FR Michel Foucher
20 partner ARLA FOODS AMBA DK Robert Svanberg
21 partner OLA AND MARTIN STEINBERG HOLDING AB SE Martin Steinberg
22 partner LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE Hans Demmelmair http://www.uni-muenchen.de
23 partner Inbio OÜ EE Harri Peiker http://www.inbiolabs.com