Pathogenesis of Type 1 Diabetes - Testing the Hygiene Hypothesis

akronüüm: DIABIMMUNE
algus: 2008-03-01
lõpp: 2013-02-28
 
programm: FP7 - Euroopa Liidu 7. raamprogramm
alaprogramm: HEALTH - Tervis
instrument: CP-FP - Väikese- ja keskmisemahulised koostööprojektid
projektikonkurss: FP7-HEALTH-2007-A
projekti number: 202063
kestus kuudes: 60
partnerite arv: 12
 
lühikokkuvõte: Preliminary data indicate that there is a strong association between the incidence of immune-mediated diseases and improving standard of living and hygiene. One of the steepest gradient in standard of living worldwide is present at the border between Russian Karelia and Finland with a sevenfold difference in the gross national product, while Estonia represents a country in rapid transition. These three populations comprise a “living laboratory” providing a unique possibility to test the hygiene hypothesis in the development of immune-mediated diseases. The incidence of type 1 diabetes (T1D) is six times lower in Russian Karelia than in Finland, whereas there are very limited differences in the frequency of risk HLA genotypes in the background population. This proposal aims at comparing (i) the frequency of beta-cell autoimmunity and other organ-specific autoantibodies; (ii) the frequency of IgE-specific sensitisation and signs of allergy; (iii) the frequency of various infections; (iv) the gut microbial flora; and (v) dietary intake in young children between the three populations. The birth cohort arm of the study aims at (i) delineating the ontogeny of the immune system by using modern tools of functional genomics; (ii) comparing the functional characteristics of regulatory T cells; (iii) characterising the gut microbial colonisation in infants; (iv) assessing the timing of exposure to foreign proteins in infancy (v) defining the interrelations between dietary factors, gut microbial flora and acute microbial infections. The objectives will be approached by studying 2000 children at the age of 3 and 5 years and by observing a birth cohort comprising about 340 subjects with HLA-conferred susceptibility to autoimmunity from birth up to the age of 3 years in each country. This proposal is expected to provide new data on the reasons and mechanisms behind the increasing rates of T1D and other immune-mediated diseases seen in most developed countries after World War II.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator HELSINGIN YLIOPISTO FI Katariina Vainio-Mattila http://www.helsinki.fi/university
2 partner HELSINGIN JA UUDENMAAN SAIRAANHOITOPIIRIN KUNTAYHTYMÄ FI Anne Karikumpu http://www.hus.fi
3 partner Tartu Ülikooli Kliinikum SA EE Vallo Tillmann http://www.kliinikum.ee
4 partner Ministry of Health and Social Development, Karelian Republic of the Russian Federation RU Valentina Ulich
5 partner TERVEYDEN JA HYVINVOINNIN LAITOS FI Jaakko Penttinen http://www.thl.fi
6 partner TAMPEREEN YLIOPISTO FI Hannele Auffermann http://www.uta.fi
7 partner TURUN YLIOPISTO FI Eliisa Särkilahti
8 partner Tartu Ülikool EE Raivo Uibo http://www.ut.ee
9 partner Immunotron OÜ EE Raivo Uibo http://www.teaduspark.ee
10 partner Petrozavodsk State University RU Natalya Dorshakova
11 partner LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE Erika Von Mutius http://www.uni-muenchen.de
12 partner ACADEMISCH ZIEKENHUIS GRONINGEN NL Elisabeth W.H.M. Eijdems http://www.umcg.nl