European Network for Genetic and Genomic Epidemiology

akronüüm: ENGAGE
algus: 2008-01-01
lõpp: 2012-12-31
 
programm: FP7 - Euroopa Liidu 7. raamprogramm
alaprogramm: HEALTH - Tervis
instrument: CP-IP - Suuremahulised integreeritud projektid
projektikonkurss: FP7-HEALTH-2007-A
projekti number: 201413
kestus kuudes: 60
partnerite arv: 26
 
lühikokkuvõte: ENGAGE (European Network for Genetic and Genomic Epidemiology) has, as its central objective, the translation of the wealth of data emerging from large-scale research efforts in molecular epidemiology into information of direct relevance to future advances in clinical medicine. ENGAGE will do this through the integration of very large-scale genetic and phenotypic data already available from a substantial number of large and well-characterised European (and other) sample sets of various types. The initial focus will be an integrated analysis of >80,000 genomewide association scans available to the consortium, thereby identifying the large number of novel disease-susceptibility variants undetectable in individual studies. Early studies will concentrate on metabolic and cardiovascular phenotypes, with subsequent expansion to apply the methods developed and lessons learned in other disease areas. The ENGAGE framework has been designed to be adaptable to advances that enable global analyses of other sources of genomic variation (eg structural and epigenetic variants), and to broadening of the phenotypic spectrum (to genomic endophenotypes in particular). The clinical and public health relevance of the novel disease- and trait-susceptibility variants we identify will be evaluated using the breadth and diversity of ENGAGE cohorts (DNAs and serum/plasma samples from over 600,000 individuals). The final step will be to effect responsible clinical translation of our major findings. As well as advances in the understanding of disease pathogenesis which may underpin novel therapeutic advances, we expect to provide clear proof-of-principle that genetic and genomic discoveries can be translated into diagnostic indicators for common diseases with the capacity to stratify risk, monitor disease progression and predict and monitor therapeutic response. ENGAGE has assembled the best researchers, clinical samples and statistical and technical expertise in Europe to realise these goals.
partneri jrk nr ja roll partneri nimi riik kontaktisik koduleht
1 koordinaator HELSINGIN YLIOPISTO FI Kaisa Ainala http://www.helsinki.fi/university
2 partner THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK Edward Gibbs http://www.ox.ac.uk
3 partner EUROPEAN MOLECULAR BIOLOGY LABORATORY DE Keith Williamson http://www.embl.org
4 partner QUEEN'S UNIVERSITY BELFAST UK Colleen Spence http://www.qub.ac.uk
5 partner KING'S COLLEGE LONDON UK Paul Labbett http://www.kcl.ac.uk
6 partner ILLUMINA CAMBRIDGE LTD UK Julie Fordham
7 partner ACADEMISCH ZIEKENHUIS LEIDEN - LEIDS UNIVERSITAIR MEDISCH CENTRUM NL Linda Ouwerkerk http://www.lumc.nl
8 partner ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL Koos (J.Th.N.) Lubbe http://www.erasmusmc.nl
9 partner HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH DE Juergen Ertel http://www.helmholtz-muenchen.de
10 partner KAROLINSKA INSTITUTET SE Agneta Häggström http://www.ki.se
11 partner LUNDS UNIVERSITET SE Lennart Råstam http://www.lu.se
12 partner UPPSALA UNIVERSITET SE Lillebil Andersson http://www.uu.se
13 partner KUNGLIGA TEKNISKA HOEGSKOLAN SE åke Eriksson http://www.kth.se
14 partner NASJONALT FOLKEHELSEINSTITUTT NO Jennifer Harris http://www.fhi.no
15 partner Tartu Ülikool EE Andres Metspalu http://www.ut.ee
16 partner ISLENSK ERFDAGREINING EHF IS Björgvin Richardsson http://www.decode.com
17 partner Ontario Institute for Cancer Research CA Jane Van Alphen
18 partner UNIVERSITE DE MONTREAL CA Denise Avard http://www.umontreal.ca
19 partner FUNDACIO PRIVADA CENTRE DE REGULACIO GENOMICA ES Oscar Fraile http://www.crg.es
20 partner UNIVERSITY OF LEICESTER UK Marie Adams http://www.le.ac.uk
21 partner UNIVERSITAET ZU LUEBECK DE Gabriele Huhn http://www.uni-luebeck.de
22 partner IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY AND MEDICINE UK Michael Robinson http://www.imperial.ac.uk
23 partner QUEENSLAND INSTITUTE OF MEDICAL RESEARCH AU Donna Hancock http://www.qimr.edu.au
24 partner GENOME RESEARCH LIMITED UK David Davison http://www.sanger.ac.uk
25 partner LATVIJAS UNIVERSITATES MATEMATIKAS UN INFORMATIKAS INSTITUTS LV Inara Opmane
26 partner ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING MCGILL UNIVERSITY CA Olga Naiberguer http://www.mcgill.ca